DMPK-PD Project Leader

At Roche you can show up as yourself, embraced for the unique qualities you bring.

Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs.

At pRED, we are united by our mission to transform science into medicine.

Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

pRED's Pharmaceutical Sciences (PS) group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines.

PS supports discovery and development across the whole value chain from target assessment to on-market and beyond.

 

The Opportunity

As an experienced DMPK-PD Project Leader within the Translational DMPK-PD and Clinical Pharmacology chapter, you will be pivotal in ensuring the right drug is delivered at the right dose, safely and efficaciously, to patients.

You will lead nonclinical and translational strategies, collaborating across therapeutic areas to transform scientific hypotheses into groundbreaking clinical candidates.

Your Impact & Responsibilities:



* Strategic Leadership: Define and lead advanced drug design, optimization strategies, and comprehensive compound profiling, integrating cutting-edge DMPK principles with target biology validation and complex translational PK/PD concepts.


* Translational Expertise: Serve as the subject matter expert, guiding early discovery teams in developing sophisticated translational strategies for clinical evaluation of target modulation, leveraging deep biochemical and pharmacological knowledge.


* Advanced Modeling & Simulation (M&S): Direct advanced M&S activities (including complex PKPD, PBPK, DDI, and sophisticated human dose/regimen prediction) to critically inform and de-risk projects from Lead Optimization (LO) through early and late-stage clinical development (EIH, Ph 2/3).


* Regulatory Mastery: Author and present definitive, high-quality scientific assessments of non-clinical DMPK data for critical internal program reviews and all major external regulatory submissions (IND, IB, CTA, NDA, BLA), ensuring global compliance and accelerated timelines.


* Implementation & Innovation: Pioneer and oversee the implementation of robust biomarker and bioa...