Senior / Principal Scientist in Pharmaceutical Development of Synthetic Molecules (Drug Product)

At Roche you can show up as yourself, embraced for the unique qualities you bring.

Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

The Position

In PTD, we collaborate to develop robust manufacturing processes and quality control systems to efficiently transform scientific ideas into products.

We reliably deliver quality products to patients enrolled in clinical studies around the world.

We excel in our work by creating an engaging and inclusive environment where everyone can bring their skills and talents to developing innovative medicines.

This position is part of the Synthetic Molecule Pharmaceutical and Solid State Development organisation (PTDC-P).

Within PTDC-P, we transform molecules to medicines through particle engineering, and develop and deliver customised clinical formulations and robust commercial drug products that benefit patients.

The Opportunity

As a Senior Scientist / Principal Scientist in Drug Product Development, you are responsible for developing robust formulations and lean manufacturing processes for oral dosage forms of new chemical entities.

In this position, you work closely with international teams, including scientists and management from other disciplines (chemistry, analytics, quality, regulatory, and commercial production), and you represent the department on technical development teams (CMC) and scientific boards.

Furthermore, you are driving scientific initiatives to ensure the department's scientific and technical excellence.

The main responsibilities of this challenging position include:



* Development and optimisation of clinical as well as commercial formulations and manufacturing processes for oral solid drug products using various manufacturing technologies (i.e.

batch and continuous mode), including the scale-up and transfers to commercial manufacturing sites to facilitate the successful process validation at the sites.


* Development and implementation of new and innovative drug delivery technologies that can be applied in regular portfolio projects.


* Application of statistical tools (e.g.

DoEs), risk assessment tools for QbD (e.g.

QRA, FMEA) and Modelling and Simulation tools.


* Regular review of scientific literature to extract relevant trends and integrate innovative concepts and technologies in the scientific strategy of the department.


* Active participation in scientific teams at Roche as well as external consortia.


* Authorship and review of technical reports, manufacturing instructions, process validation documents, and the CMC parts of regulatory submissions to support market authorisation. 


* Contributing actively to the i...