Principal Scientist, Muscle Biology - Aging & Metabolism

At Johnson & Johnson, we believe health is everything.

Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biological Research

Job Category:
Scientific/Technology

All Job Posting Locations:
Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements.

Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Muscle Biology - Aging & Metabolism to be in Spring House, PA or Cambridge, MA. 
 

Purpose: 
The Principal Scientist plays a pivotal role in shaping drug discovery and translational research strategies to address aging-related degenerative diseases.

This position leverages deep expertise in muscle biology to accelerate therapeutic development for conditions such as cardiovascular disease, thrombosis, and sarcopenia.

Additionally, the role contributes to J&J therapeutic initiatives across neuroscience, immunology, and oncology.

 
 

You will be responsible for:
•    Provide scientific leadership and drug discovery expertise in skeletal, cardiac, and smooth muscle biology, driving innovation in therapeutic approaches for age-related diseases. 
•    Proficiency in in vivo and in vitro studies execution and animal models expertise in age-related pathogenesis is essential.
•    Support strategic collaborations across J&J’s Cross-Therapeutic Area (TA) and MedTech teams, leveraging interdisciplinary expertise to accelerate biomarker and therapeutic development.
•    Support the evaluation of early- and late-stage assets, guiding translational strategies for novel and repurposed candidates.

 
•    Foster strong partnerships across internal and external teams, including biologists, technical experts, clinicians, and external research collaborators to advance therapeutic programs.

 
•    Build and maintain strong collaborations within the TA (TA R&D, Clinical Development, DPDS) and partnering functions (Regulatory, Global Development, Medical Affairs, Commercial).

Qualifications / Requirements:
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